期刊
ACTA PHARMACEUTICA SINICA B
卷 8, 期 5, 页码 767-771出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2018.07.001
关键词
SGK; AKT; PI3K; Cancer; Signalling: Kinase; Inhibitor
资金
- Ministry of Science and Technology of China [2014DFG32200]
- Shanghai Science and Technology Development Fund [15DZ2291600]
- Thousand Talents Program in China [[2011]166]
The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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