期刊
ACTA PHARMACEUTICA SINICA B
卷 8, 期 2, 页码 165-177出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2018.01.007
关键词
Mesoporous silica nanoparticles; Poorly soluble drug; Cancer therapy; Multidrug resistance; Gene delivery
资金
- National Natural Science Foundation of China [81473155]
- Natural Science Fund Project of Guangdong Province [2016A030312013]
- Science and Technology Plan Projects of Guangdong Province [2015B020232010]
- Science and Technology Foundation Guangzhou [201707010103]
Mesoporous silica nanoparticles (MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume, selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly, the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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