期刊
ACTA PHARMACEUTICA SINICA B
卷 8, 期 1, 页码 51-63出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2017.11.006
关键词
Biomimetic nanocarrier; Reconstituted high-density lipoprotein; Biological barriers; Efficient targeting; Nanodrug delivery systems
资金
- National Natural Science Foundation of China [81373351, 81573382, 81722043]
- Shanghai Science and Technology Committee [15540723700]
- Shu Guang project - Shanghai Municipal Education Commission
- Shanghai Education Development Foundation [15SG14]
High-density lipoproteins (HDL) are naturally-occurring nanoparticles that are biocompatible, non-immunogenic and completely biodegradable. These endogenous particles can circulate for an extended period of time and transport lipids, proteins and microRNA from donor cells to recipient cells. Based on their intrinsic targeting properties, HDL are regarded as promising drug delivery systems. In order to produce on a large scale and to avoid blood borne pollution, reconstituted high-density lipoproteins (rHDL) possessing the biological properties of HDL have been developed. This review summarizes the biological properties and biomedical applications of rHDL as drug delivery platforms. It focuses on the emerging approaches that have been developed for the generation of biomimetic nanoparticles rHDL to overcome the biological barriers to drug delivery, aiming to provide an alternative, promising avenue for efficient targeting transport of nanomedicine. (C) 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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