期刊
EBIOMEDICINE
卷 32, 期 -, 页码 164-171出版社
ELSEVIER
DOI: 10.1016/j.ebiom.2018.05.033
关键词
Adiponectin-associated locus; CDH13; Adiponectin; Left ventricular mass index; Sleep time
资金
- Beijing Municipal Science & Technology Commission [D111100000611001, D111100000611002]
- National Key Research program of China [2016YFC1304801]
- Beijing Natural Science Foundation [7172169]
- Development Program of Beijing Chaoyang Hospital [JXPY201606]
- Graduate innovation fund of Peking Union Medical College [2017-1002-1-15]
- Beijing Science & Technology Star Program [2004A027]
- Novo Nordisk Union Diabetes Research Talent Fund [2011A002]
- National Key Program of Clinical Science [WBYZ 2011-873]
Left ventricular mass index (LVMI) provides a metric for cardiovascular disease risk. We aimed to assess the association of adiponectin-related genetic variants resulting from GWAS in East Asians (loci in/near CDH13, ADIPOQ, WDR11FGF, CMIP and PEPD) with LVMI, and to examine whether sleep duration modified these genetic associations in youth. The 559 subjects aged 15-28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome study. Among the six loci, CDH13 rs4783244 was significantly correlated with adiponectin levels (p = 8.07 x 10(-7)). The adiponectin-rising allele in rs4783244 locus was significantly associated with decreased LVMI (p = 6.99 x 10(-4)) after adjusting for classical cardiovascular risk factors, and further for adiponectin levels, while no significant associationwas found between the other loci and LVMI. Moreover, we observed a significant interaction effect between rs4783244 and sleep duration (p =. 005) for LVMI; the genetic association was more evident in long sleep duration while lost in short sleep duration. Similar interaction was found in the subgroup analysis using longitudinal data (p =. 025 for interaction). In this young Chinese population, CDH13 rs4783244 represents a key locus for cardiac structure, and confers stronger cardio-protection in longer sleep duration when contrasted with short sleep duration. (C) 2018 The Authors. Published by Elsevier B.V.
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