期刊
EBIOMEDICINE
卷 28, 期 -, 页码 31-42出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ebiom.2018.01.025
关键词
Ischemia-reperfusion; Graft survival; Renal transplantation; Acute rejection; Th cells: T helper cells
资金
- British Medical Research Council (MRC)
- Developmental Pathway Funding Scheme (DPFS) program [G802392]
- BJA/RCoA Research Fellowship grant
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific inflammatory responses that can result in the loss of kidney graft viability. However, the long-term consequence of IRI on renal grafts survival is uncertain. Herewe reviewclinical evidence and laboratory studies, and elucidate the association between early IRI and later graft loss. Our critical analysis of previous publications indicates that early IRI does contribute to later graft loss through reduction of renal functional mass, graft vascular injury, and chronic hypoxia, as well as subsequent fibrosis. IRI is also known to induce kidney allograft dysfunction and acute rejection, reducing graft survival. Therefore, attempts have been made to substitute traditional preserving solutions with novel agents, yielding promising results. (c) 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license
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