期刊
SCIENCE ADVANCES
卷 4, 期 3, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aap7399
关键词
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资金
- UK Biotechnology and Biological Sciences Research Council [BB/J014478/1]
- Wellcome Trust [WT 100290MA]
- University of Manchester Strategic Fund
- Medical Research Council [G1100076]
- Wellcome Trust Centre for Cell Matrix Research Centre [203128/Z/16/Z]
- Biotechnology and Biological Sciences Research Council [1575087] Funding Source: researchfish
- Medical Research Council [G1100076] Funding Source: researchfish
- Wellcome Trust [100290/Z/12/Z] Funding Source: researchfish
- MRC [G1100076] Funding Source: UKRI
- Wellcome Trust [100290/Z/12/Z] Funding Source: Wellcome Trust
Intestinal dwelling parasites have evolved closely with the complex intestinal microbiota of their host, but the significance of the host microbiota for metazoan pathogens and the role of their own intestinal microbiota are still not fully known. We have found that the parasitic nematode Trichuris muris acquired a distinct intestinal microbiota from its host, which was required for nematode fitness. Infection of germ-free mice and mice monocolonized with Bacteroides thetaiotaomicron demonstrated that successful T. muris infections require a host microbiota. Following infection, T. muris-induced alterations in the host intestinal microbiota inhibited subsequent rounds of infection, controlling parasite numbers within the host intestine. This dual strategy could promote the long-term survival of the parasite within the intestinal niche necessary for successful chronic nematode infection.
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