期刊
SCIENCE ADVANCES
卷 4, 期 7, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aat6031
关键词
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资金
- Swiss National Science Foundation [200020_152782, 200020_172621]
- State Secretariat for Education, Research and Innovation (SERI
- SBFI) [C14.0096]
- SERI via the Swiss Government Excellence Scholarships for Foreign Scholars and Artists
- Novartis Foundation for Medical-Biological Research
- Swiss National Science Foundation (SNF) [200020_152782] Funding Source: Swiss National Science Foundation (SNF)
The concept of repair is widely used by nature to heal molecules such as proteins, lipids, sugars, and DNA that are damaged by hydrogen atom abstraction resulting from oxidative stress. We show that this strategy, rather undocumented in the field of synthetic organic chemistry, can be used in a radical chain reaction to enable notoriously intractable transformations. By overcoming the radical chain inhibitor properties of substituted alkenes, the radical-mediated hydroalkylation of mono-, di-, tri-, and even tetrasubstituted unactivated olefins could be performed under mild conditions. With a remarkable functional group tolerance, this reaction provides a general coupling method for the derivatization of olefin-containing natural products.
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