期刊
CHEM
卷 4, 期 5, 页码 1128-1138出版社
CELL PRESS
DOI: 10.1016/j.chempr.2018.02.016
关键词
-
资金
- A*STAR (Agency for Science, Technology, and Research of Singapore) Biomedical Research Council
- National Medical Research Council [NMRC/TCR/016-NNI/2016]
- Ministry of Science & ICT (MSIT), Republic of Korea [IBS-R007-D1-2018-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Elastic fibers are present in a variety of tissues and are responsible for their resilience. Until now, no optical contrast agent in the near-infrared (NIR) wavelength range of 700-900 nm has been reported for the imaging of elastic fibers. Here, we report the discovery of a NIR zwitterionic elastin probe ElaNIR (elastin NIR) through fluorescent-image-based screening. The probe was successfully applied for in vitro, ex vivo, and in vivo imaging by various imaging modalities. Age-related elastin differences shown by in vivo fluorescent and photoacoustic imaging indicated that ElaNIR can be a potentially convenient tool for uncovering changes of elastin in live models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据