期刊
CHEM
卷 4, 期 5, 页码 1047-1058出版社
CELL PRESS
DOI: 10.1016/j.chempr.2018.03.010
关键词
-
资金
- National Natural Science Foundation of China [21502183, 21772184]
- Chinese Academy of Science [XDB20000000]
Mimicking the way nature synthesizes organic molecules, multi-catalyst relay catalysis (MCRC), based on the seamless combination of a series of catalytic reactions, has emerged as a promising strategy for achieving ideal synthesis. In such systems, each step takes place orderly and sequentially. Taken as a whole, the entire process appears indistinguishable from a common one-step reaction but provides a means for extraordinary transformations. Here, we report a one-step transformation of styrenes, allylic alcohols, and syngas to alpha-quaternary chiral aldehydes in a multi-catalyst system consisting of a rhodium(I) complex, a palladium(0) complex, a chiral Bronsted acid catalyst, and an achiral amine (20-100 mol %). The cascade hydroformylation and asymmetric allylation reaction was realized with high yields (up to 98%) and high enantioselectivities (up to 99% ee) under mild conditions (1 bar of syngas).
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