期刊
NATURE REVIEWS CANCER
卷 11, 期 10, 页码 735-748出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3125
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资金
- Brewster Foundation
- Champalimaud Foundation
- American Cancer Society
- Komen for the Cure
- New Jersey Commission on Cancer Research
- US Department of Defense
- US National Institutes of Health [R01CA134519, R01CA141062]
Despite recognizing the devastating consequences of metastasis, we are not yet able to effectively treat cancer that has spread to vital organs. The inherent complexity of genomic alterations in late-stage cancers, coupled with numerous heterotypic interactions that occur between tumour and stromal cells, represent fundamental challenges in our quest to understand and control metastatic disease. The incorporation of genomic and other systems level approaches, as well as technological breakthroughs in imaging and animal modelling, have galvanized the effort to overcome gaps in our understanding of metastasis. Future research carries with it the potential to translate the wealth of new knowledge and conceptual advances into effective targeted therapies.
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