期刊
NATURE MICROBIOLOGY
卷 3, 期 3, 页码 356-366出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41564-017-0084-4
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资金
- STARR Cancer Consortium [I7-A714]
- NCI [R01CA202704, U01CA152904, UM1 CA167552]
- NIDDK [DK098311, U54DE023798]
- Nebraska Tobacco Settlement Biomedical Research Development Funds
- National Health and Medical Research Council
- Howard Hughes Medical Institute Fellowship
The gut microbiome is intimately related to human health, but it is not yet known which functional activities are driven by specific microorganisms' ecological configurations or transcription. We report a large-scale investigation of 372 human faecal metatranscriptomes and 929 metagenomes from a subset of 308 men in the Health Professionals Follow-Up Study. We identified a metatranscriptomic 'core' universally transcribed over time and across participants, often by different microorganisms. In contrast to the housekeeping functions enriched in this core, a 'variable' metatranscriptome included specialized pathways that were differentially expressed both across participants and among microorganisms. Finally, longitudinal metagenomic profiles allowed ecological interaction network reconstruction, which remained stable over the six-month timespan, as did strain tracking within and between participants. These results provide an initial characterization of human faecal microbial ecology into core, subject-specific, microorganism-specific and temporally variable transcription, and they differentiate metagenomically versus metatranscriptomically informative aspects of the human faecal microbiome.
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