期刊
CHEMISTRYSELECT
卷 3, 期 22, 页码 6195-6202出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201800816
关键词
Azides; Copper nanoparticles; Dicarbonyl compounds; 1,3-dipolar cycloaddition; Heterogeneous catalysis
资金
- GlaxoSmithKline FAPESP [2014/50249-8]
- Sao Paulo Research Foundation (FAPESP) [2013/06558-3]
- FAPESP/GSK [2017/06536-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/06536-0, 13/06558-3] Funding Source: FAPESP
Substituted 1,2,3-triazoles are important heterocyclic molecules with applications in diverse research areas. The organocatalytic (3+2) cycloaddition reaction of azides with active methylene compounds has proven to be a powerful strategy for the synthesis of a variety of 1,2,3-triazoles with different substituents. However the reported methods in the literature, commonly used a homogenous organocatalyst. Considering this point, here we have reported a novel heterogeneous protocol for the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles by reaction of different dicarbonyl compounds with aryl azides catalyzed by copper oxide nanoparticles under microwave irradiation. The important features of this methodology are high yield products, short reaction times and recyclability of the CuO catalyst.
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