期刊
CHEMISTRYSELECT
卷 3, 期 8, 页码 2332-2335出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201702888
关键词
AIE; invitro; pH sensitive; photodynamic therapy
资金
- Natural Science Foundation of Jiangsu Province [BK2012210]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [10KJB430001]
- Opening Fund of Jiangsu Key Laboratory of Advanced Functional Materials [12KFJJ010]
It is of great significance to develop compounds that can be soluble or dispersible in water and simultaneously remain high fluorescent in aqueous media. Compounds with aggregation induced emission (AIE) have a great potential as cell imaging agents. In this paper, 4,4,4,4-(ethene-1,1,2,2-tetrayl)tetrakis(N,N-diethylaniline) (denoted as ETTDA) with AIE was designed and prepared. DSPE-PEG(-2000) (1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)-Folate (sodium salt)(-2000)) coated ETTDA nanoparticles (NPs) were used for treatment of four different kinds of cancer cells (HCT-116 (human colon cancer cell), A549 (human caucasian lung carcinoma), Hela (human cervical cancer cells) and A2780 (ovarian carcinoma cells)) and cytotoxicity investigation shows it is highly sensitive to Hela, moderate sensitive to A549 and A2780 but low sensitive to HCT-116. Furthermore, cell migration of ETTDA nanoparticles (NPs) on Hela shows that ETTDA NPs are capable of inhibiting the migration of Hela invitro, indicating its potential ability to interfere with the transfer of tumor invivo.
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