期刊
CHEMISTRYSELECT
卷 3, 期 6, 页码 1915-1918出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201702788
关键词
Baclofen; 3-methyl-4-nitro-5-styrylisoxazoles; Michael addition; nitromethane; WERSA
Herein, we describe a mild and convenient protocol for Michael addition of nitroalkanes to 3-methyl-4-nitro-5-styrylisoxazoles using neat water extract of rice straw ash (WERSA) as a catalyst and medium at room temperature. Method developed is simple to operate and yields range from good to excellent. This eco-friendly protocol also successfully used for the synthesis of pharmaceutical interest, such as gamma-nitrobutyricacid an intermediate for the preparation of Baclofen.
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