期刊
ACS SENSORS
卷 3, 期 7, 页码 1222-1232出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.8b00340
关键词
compact disc (CD); digital versatile disc (DVD); Blu-ray; pptical pickup-unit (OPU); nanobio imaging; cytometer; optical tweezer; DNA chip; fluorescence; medical diagnostics
资金
- European Research Council under the European Union's Seventh Framework Program (FP7/2007-2013) [320535-HERMES]
- Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN) - Danish National Research Foundation [DNRF122]
- Velux Foundations
The optical pickup unit (OPU) within a CD/DVD/Blu-ray drive integrates 780, 650, and 405 nm wavelength lasers, diffraction-limited optics, a high-bandwidth optoelectronic transducer up to 400 MHz, and a nano resolution x-, z-axis, and tilt actuator in a compact size. In addition, the OPU is a remarkable piece of engineering and could enable different scientific applications such as sub angstrom displacement sensing, micro- and nanoimaging, and nanolithography. Although off-the-shelf OPUs can be easily obtained, manufacturers protect their datasheets under nondisclosure agreements to impede their availability to the public. Thus, OPUs are black boxes that few people can use for research, and only experienced researchers can access all their functions. This review details the OPU mechanism and components. In addition, we explain how to utilize three commercially available triple-wavelength OPUs from scratch and optimize sensing quality. Then, we discuss scientific research using OPUs, from standard optical drive-based turnkey-biomarker array reading and OPU direct bioapplications (cytometry, optical tweezing, bioimaging) to modified OPU-based biosensing (DNA chip fluorescence scanning, biomolecular diagnostics). We conclude by presenting future trends on optical storage devices and potential applications. Hacking low-cost and high-performance OPUs may spread micro- and nanoscale biosensing research from research laboratories to citizen scientists around the globe.
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