期刊
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
卷 25, 期 3, 页码 735-738出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1078155218755547
关键词
Antiemetics; aprepitant; bone cancer; nausea; vomiting
资金
- Brazilian Ministry of Education (Residencia Integrada Multiprofissional em Saude)
An eight-year long case series follow-up study with pediatric bone cancer patients was conducted to compare the occurrence of adverse events associated with aprepitant with official sources of drug information (manufacturer's leaflet, clinical trials, and European Medicines Agency leaflet). All patients admitted were analyzed, representing 192 aprepitant cycles. Anorexia, febrile neutropenia, and headache were observed in frequencies over 43.8 per 100 patients, which was higher than previous estimates. Adverse events were classified as probable or possible, by using Naranjo score. The increased rates of adverse events, especially on the risk febrile neutropenia, warrant further safety studies on this population.
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