期刊
DEVELOPMENT AND PSYCHOPATHOLOGY
卷 23, 期 4, 页码 1039-1058出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0954579411000484
关键词
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资金
- NCRR NIH HHS [1UL1RR025011, UL1 RR025011-05, UL1 RR025011, UL1 RR025011-03, UL1 RR025011-04] Funding Source: Medline
- NICHD NIH HHS [P30 HD003352] Funding Source: Medline
- NIMH NIH HHS [P50 MH069315-05, K01 MH077687-05, R01 MH044340-09S1A1, P50 MH084051-03, P50 MH069315-02, P50-MH069315, K01 MH077687-04, R01 MH044340-09, K01 MH077687-02, P50 MH069315-01, P50 MH052354-09, P50-MH052354, P50 MH052354-08, K01 MH077687, R01-MH044340, P50 MH069315-04, P50 MH084051-04, P50 MH052354-07, P50 MH052354-10, P50 MH069315, K01 MH077687-06, P50 MH069315-03, K01 MH077687-03, K01-MH077687, P50-MH084051, K01 MH077687-01A1, P50 MH052354-07S1, P50 MH084051-02, P50 MH084051, P50 MH084051-01, R01 MH044340-09S2] Funding Source: Medline
The hypothalamic-pituitary-adrenal (HPA) axis is a primary mechanism in the allostatic process through which early life stress (ELS) contributes to disease. Studies of the influence of ELS on children's HPA axis functioning have yielded inconsistent findings. To address this issue, the present study considers multiple types of ELS (maternal depression, paternal depression, and family expressed anger), mental health symptoms, and two components of HPA functioning (traitlike and epoch-specific activity) in a long-term prospective community study of 357 children. ELS was assessed during the infancy and preschool periods; mental health symptoms and cortisol were assessed at child ages 9, 11, 13, and 15 years. A three-level hierarchical linear model addressed questions regarding the influences of ELS on HPA functioning and its covariation with mental health symptoms. ELS influenced traitlike cortisol level and slope, with both hyper- and hypoarousal evident depending on type of ELS. Further, type(s) of ELS influenced covariation of epoch-specific HPA functioning and mental health symptoms, with a tighter coupling of HPA alterations with symptom severity among children exposed previously to ELS. Results highlight the importance of examining multiple types of ELS and dynamic HPA functioning in order to capture the allostatic process unfolding across the transition into adolescence.
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