期刊
FRONTIERS IN PSYCHIATRY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2018.00222
关键词
enkephalin; cocaine; amphetamine; neuroadaptations; addiction; opioid antagonists
类别
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) [PID 11420110100354]
- Secretaria de Ciencia y Tecnica (SeCyT) [202/16]
- Fondo para la Investigacion Cientifica y Tecnologica (FONCyT)
- Ministerio de Ciencia y Tecnica Argentina (MinCyT) [PICT 2015-1622]
Enkephalin expression is high in mesocorticolimbic areas associated with psychostimulant-induced behavioral and neurobiological effects, and may also modulate local neurotransmission in this circuit network. Psychostimulant drugs, like amphetamine and cocaine, significantly increase the content of enkephalin in these brain structures, but we do not yet understand the specific significance of this drug-induced adaptation. In this review, we summarize the neurochemical and molecular mechanism of psychostimulant-induced enkephalin activation in mesocorticolimbic brain areas, and the contribution of this opioid peptide in the pivotal neuroadaptations and long-term behavioral changes underlying psychostimulant addiction. There is evidence suggesting that adaptive changes in enkephalin content in the mesocorticolimbic circuit, induced by acute and chronic psychostimulant administration, may represent a key initial step in the long-term behavioral and neuronal plasticity induced by these drugs.
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