期刊
FRONTIERS IN PSYCHIATRY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2018.00014
关键词
cognitive enhancer; biomarker; sodium benzoate; D-amino acid oxidase; glycine
类别
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Global Brain Health Institute [GBHI_ALZ-18-544160]
- Alzheimer's Association [GBHI_ALZ-18-544160]
After 25 years of its discovery in the rat brain, D-serine is a recognized modulator of synaptic plasticity and cognitive processes through its actions on the NMDA-glutamate receptor. Importantly, cognitive impairment is a core feature of conditions, such as schizophrenia, Alzheimer's disease, depression, and aging, and is associated to disturbances in NMDA-glutamate receptors. The D-serine pathway has been associated with cognitive deficits and these conditions, and, for this reason, D-serine signaling is subject of intense research to probe its role in aiding diagnosis and therapy. Nevertheless, this has not resulted in new therapies being incorporated into clinical practice. Therefore, in this review we will address many questions that need to be solved by future studies, regarding D-serine pharmacokinetics, possible side effects, other strategies to modulate its levels, and combination with other therapies to increase its efficacy.
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