期刊
FRONTIERS IN ENDOCRINOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2018.00238
关键词
continuous glucose monitoring; body composition; adiposity; glycemia; glycemic variability
资金
- Philips Consumer Lifestyle
- Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO) [05040202, 050-060-810]
- European Commission project Switchbox [Health-F2-2010-259772]
- Netherlands Consortium for Healthy Aging [050-060-810]
- European Commission [Health-2013-INNOVATION-1-602757]
Background: It is well known that adiposity is a risk factor for insulin resistance and type 2 diabetes mellitus. In the present study, we aimed to investigate the associations of measures of adiposity with indices of glycemia and of glycemic variability over a 72-h period in non-diabetic older adults. Methods: This cross-sectional study was conducted in non-diabetic individuals from the Active and Healthy Aging Study (N = 228), Switchbox (N = 116), and the Growing Old Together Study (N = 94). Body mass index (BMI) and waist circumference were measured, and indices of glycemia and glycemic variability were derived from continuous glucose monitoring (CGM) using the Mini-Med CGM system. Associations between adiposity and CGM were studied separately for the three cohorts, and derived estimates were subsequently meta-analyzed. Results: After meta-analyzing the results from the separate cohorts, individuals with a higher BMI had higher levels of glycemia. Individuals with BMI between 30 and 35 kg/m(2) had 0.28 mmol/L [95% confidence interval (Cl): 0.12-0.44] higher 72 h-mean glucose concentration, 0.26 mmol/L (0.10-0.42) higher diurnal glucose (6:00 a.m. to 0:00 a.m.), and 0.39 mmol/L (0.19; 0.59) higher nocturnal glucose (3:00 a.m. to 6:00 a.m.) than participants with a normal weight (BMI 18.5-25 kg/m(2)). However, no associations were observed between higher BMI and glycemic variability. Results: for glycemia and glycemic variability were similarly observed for a high waist circumference. Conclusion: High adiposity associates with constant higher mean glucose levels over the day in non-diabetic older adults.
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