期刊
CANCER MANAGEMENT AND RESEARCH
卷 10, 期 -, 页码 1037-1050出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S162105
关键词
hepatocellular carcinoma susceptibility; genetic polymorphism; ALDH2; CYP2E1; Chinese population
类别
资金
- Common Fund of the Office of the Director of the National Institutes of Health
- National Nature Science Foundation of China [81560535, 81072321, 30760243, 30460143, 30560133]
- 2009 Program for New Century Excellent Talents in University (NCET)
- Guangxi Nature Sciences Foundation [GuiKeGong 1104003A-7]
- Guangxi Health Ministry Medicine Grant [Z201018]
- Innovation Project of Guangxi Graduate Education [JGY2018037]
- Self-raised Scientific Research Fund of the Health and Family Planning Commission of Guangxi Zhuang Autonomous Region [Z2016318]
- National Cancer Institute
- National Human Genome Research Institute
- National Heart, Lung and Blood Institute
- National Institute on Drug Abuse
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
Objective: Acetaldehyde dehydrogenase 2 (ALDH2) and cytochrome P450 2E1 (CYP2E1) have been associated with hepatocellular carcinoma (HCC) susceptibility and prognosis. The polymorphisms ALDH2 rs671 and CYP2E1 rs2031920 are reportedly correlated with the prevalence of HCC in other countries. The aim of this study was to investigate associations between ALDH2 and CYP2E1, and HCC susceptibility in a population of Guangxi, southern China, an area with a high incidence of HCC. Patients and methods: The study cohort included 300 HCC cases, 292 healthy controls for HCC susceptibility analysis, and another 20 HCC cases and 10 healthy controls for ascertainment. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. Results: The study results demonstrated that mutant genotypes of ALDH2 (G/A and A/A) led to significant differences in HCC susceptibility, as compared with the wild genotype (G/G) with the same C1/C1 genotype in non-drinking individuals (adjusted P=0.010, OR=0.20, 95% CI=0.06-0.68). The mutant genotypes of CYP2E1 (C1/C2 and C2/C2) brought about significant differences in HCC susceptibility, as compared with the wild genotype (C1/C1) and the same G/G genotype (adjusted P=0.025, OR=0.42, 95% CI=0.20-0.90). Drinking plays a role in HCC susceptibility in the same G/G genotype individuals (adjusted P=0.004, OR=0.32, 95% CI=0.15-0.69), but had no impact when combined with CYP2E1 for analysis (all P>0.05). Conclusion: These results suggest that the mutant genotypes of ALDH2 and CYP2E1 may be protective factors for HCC susceptibility in Guangxi province, China.
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