4.3 Article

Circular RNAs and competing endogenous RNA (ceRNA) networks

期刊

TRANSLATIONAL CANCER RESEARCH
卷 7, 期 -, 页码 S624-S628

出版社

AME PUBL CO
DOI: 10.21037/tcr.2018.05.12

关键词

Circular RNAs (circRNAs); microRNAs; miRNA; ceRNA networks

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资金

  1. National Institutes of Health Division of Intramural Research [ZIA HD001804]
  2. EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [ZIAHD001804] Funding Source: NIH RePORTER

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In recent years, advances in bioinformatics approaches have allowed a systematic characterization of circular RNAs (circRNAs) across a variety of cell types. Demonstration of cell type specificity, regulated expression, and conservation between species all suggest that circRNAs have functional importance. Especially, investigators have begun focusing on the possibility that circRNAs operate as part of competing endogenous RNA (ceRNA) regulatory networks that are proposed to play critical roles in normal development and in pathologic conditions like cancer.

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