期刊
SCIENCE BULLETIN
卷 63, 期 16, 页码 1059-1066出版社
SCIENCE PRESS
DOI: 10.1016/j.scib.2018.07.017
关键词
Lipid A; MCR-1; Colistin resistance; Transferable resistance to polymyxin; Intrinsic colistin resistance; Gut bacteria; Microbiome
资金
- National Key R&D Program of China [2017YFD0500202]
- National Key Basic Research Program of China [2016YFC1200100]
- National Natural Science Foundation of China [31570027, 81772142]
- Young 1000 Talents Award
An endemic multi-drug resistant ST117 E. coli isolate coproducing MCR-1 and 3 ESBL loci was, for the first time, detected from diseased chicken, Liaoning Province, in Northeast China, from 2011 to 2012. Whole-genome sequencing revealed 5 unique plasmids, namely pHXH-1, pHXH-2, pHXH-3, pHXH-4 and pHXH-5). Among them, pHXH1 and pHXH4 encode ESBL, and pHXH-5 mediates MCR-1 colistin resistance. The results indicate that the potentially-national dissemination of MCR-1-positive pathogens with pan-drug resistance proceeds via food chains. (C) 2018 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
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