期刊
REDOX BIOLOGY
卷 14, 期 -, 页码 386-390出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2017.10.003
关键词
Aging; Temperature; C. elegans; Oxidants; Peroxiredoxin
资金
- National Institute of Health [AG027349, R35-GM-122506]
- NIH Office of Research Infrastructure Programs [P40 OD010440]
Lifespan in poikilothermic organisms, such as Caenorhabditis elegans, can be substantially increased simply by decreasing growth temperature. To gain insights into the mechanistic underpinnings of this effect, we investigated the effects of temperature in development and adulthood on C. elegans lifespan. We found that worms exposed to 25 degrees C during development and shifted to 15 degrees C in adulthood exhibited an even longer lifespan than animals constantly kept at 15 degrees C. Analysis of the in vivo redox status demonstrated that at 25 degrees C, C. elegans larvae have a more reduced redox state and higher Prdx-2 expression levels than animals raised at 15 degrees C. Worms lacking prdx-2 fail to show the additional lifespan extension upon shift from 25 degrees C to 15 degrees C and reveal a lifespan similar to prdx-2 worms always kept at 15 degrees C. These results suggest that transiently altering the in vivo redox state during development can have highly beneficial long-term consequences for organisms.
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