期刊
PROBIOTICS AND ANTIMICROBIAL PROTEINS
卷 11, 期 2, 页码 723-729出版社
SPRINGER
DOI: 10.1007/s12602-018-9410-2
关键词
Viable counts; ACE inhibitory activity; Response surface methodology; Goat milk
资金
- Scientific Research Program - Shaanxi Provincial Education Department [17JF005]
- Science and Technology Innovation Project co-ordination Program of Shaanxi Province [2016KTZDNY02-08]
- Doctoral Scientific Research Fund from Shaanxi University of Science and Technology [2017BJ-04]
Hypertension is a serious threat to human health and food-derived angiotensin converting enzyme (ACE; EC 3.4.15.1) inhibitory peptides can be used to regulate high blood pressure without side effects. The composition of the nutrient medium for the production of these peptides by fermenting goat milk with Lactobacillus bulgaricus LB6 was optimized to increase the ACE inhibitory activity by Box-Behnken design (BBD) of response surface methodology (RSM) in the present study. Soybean peptone, glucose, and casein had significant effects on both ACE inhibition rate and viable counts of L. bulgaricus LB6 during incubation. The results showed that the maximum values of ACE inhibition rate and viable counts for L. bulgaricus LB6 were reaching to 86.37 +/- 0.53% and 8.06x10(7) under the optimal conditions, which were 0.35% (w/w) soybean peptone, 1.2% (w/w) glucose, and 0.15% (w/w) casein. The results were in close agreement with the model prediction. The optimal values of the medium component concentrations can be a good reference for obtaining ACE inhibitory peptides from goat milk.
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