期刊
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
卷 11, 期 -, 页码 32-37出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.preghy.2017.12.006
关键词
PCOS; BMI; Hypertensive disorders of pregnancy; Obesity; Preeclampsia; RHINE
资金
- Norwegian Research Council [214123]
- Bergen Medical Research Foundation
- Western Norwegian Regional Health Authorities [911892, 911631]
- Norwegian Labor Inspection
- Norwegian Asthma and Allergy Association
- Faculty of Health at Aarhus University [240008]
- Wood and Dust Foundation [444508795]
- Danish Lung Association
- Swedish Heart and Lung Foundation
- Vardal Foundation for Health Care Science and Allergy Research
- Swedish Council for Working Life and Social Research
- Bror Hjerpstedt Foundation
- Swedish Asthma and Allergy Association
- Icelandic Research Council
- Estonian Science Foundation [4350]
Objective: Some studies of women with polycystic ovary syndrome (PCOS) report increased prevalence of hypertensive disorders in pregnancy, while others do not. Several of these studies do not control for obesity. We aimed to study whether PCOS is associated with hypertensive disorders in pregnancy and whether it is dependent on body mass index (BMI). Study design: We present a cross-sectional analysis of 3732 women from Denmark, Estonia, Iceland, Norway and Sweden, born in 1945-72, who participated in the Respiratory Health In Northern Europe (RHINE) study and answered an extensive women's health questionnaire on menstruation, PCOS, infertility, pregnancy history and childbirth. The main outcome measurement was hypertensive disorders of pregnancy. We adjusted for smoking, age, infertility treatment and study center. Effect modification by BMI was assessed. Results: PCOS was related to hypertensive disorders in pregnancy with a relative risk (RR) of 1.62 (95% CI 1.09-2.42). This relationship was found among underweight women with a BMI of <18.5 kg/m(2) [RR=5.2 (95% CI 1.66-16.5)] and obese women with a BMI of >= 30 kg/m(2) [RR=2.36 (95% CI 1.29-4.31)], but not among normal-weight women, BMI 18.5-25 kg/m(2) [1.08 (0.53-2.20)], or overweight women, BMI 25-30 kg/m(2) [1.24 (0.50-3.08)] (p-interaction=0.041). Conclusion: Polycystic ovary syndrome is associated with hypertensive disorders in pregnancy. This association only occurs among underweight and obese women and not among normal-weight and slightly overweight women.
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