期刊
ORGANIC CHEMISTRY FRONTIERS
卷 5, 期 10, 页码 1689-1697出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00229k
关键词
-
资金
- National Natural Science Foundation of China [21572078, 21772062]
A highly selective remote C-H trifluoromethylation of 8-aminoquinoline scaffolds in the C5-position with CF3SO2Na under visible light irradiation without an external photocatalyst has been developed. The protocol employs commercially available sodium trifluoromethanesulfinate (CF3SO2Na) as a trifluoromethylation reagent and shows a broad substrate scope, generating various 5-trifluoromethylated quinolines in good yields under photocatalyst-free, simple and mild conditions. Investigations indicated that both the starting material and product act as photosensitizers and O-1(2) coexists with O-2(-) during the reaction through energy transfer and single electron transfer processes. It is important to note that the electronic effect of the CF3 group as a substituent introduced into quinoline rings makes their trifluoromethylation more efficient under photo-irradiation from ultraviolet to visible light in the absence of an external photocatalyst.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据