期刊
ONCOIMMUNOLOGY
卷 7, 期 8, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2018.1465167
关键词
chronic lymphocytic leukemia; tumor microenvironment; immunotherapy; immune-checkpoint blockade; mass cytometry
资金
- Fonds National de la Recherche Luxembourg (FNR) [INTER/DFG/11509946]
- Fonds de la Recherche Scientifique (FNRS) [Televie/7.4508.16]
- Luxembourg Institute of Health (HEMATEXO)
In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.
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