期刊
MOLECULAR METABOLISM
卷 9, 期 -, 页码 176-186出版社
ELSEVIER
DOI: 10.1016/j.molmet.2018.01.015
关键词
Weight cycling; Metabolic syndrome; miRNAs; Ventromedial hypothalamus; High fat diet; Diabetes
资金
- European Research Council [260463]
- Israel Science Foundation [1565/15, 1916/12]
- Chief Scientist Office of the Israeli Ministry of Health [311389]
- Federal Ministry of Education and Research [01KU1501A]
- I-CORE Program of the Planning and Budgeting Committee
- Nella and Leon Benoziyo Center for Neurological Diseases
- Henry Chanoch Krenter Institute for Biomedical Imaging and Genomics
- Perlman Family Foundation
- Adelis Foundation
- Marc Besen and the Pratt Foundation
- Irving I. Moskowitz Foundation
- Bruno and Simone Licht
Consumption of a low calorie diet is the most common approach to lose weight. While generally effective at first, it is frequently followed by a relapse where the pre-diet weight is regained, and often exceeded. This pattern of repeated weight loss/regain is referred to as weight cycling and the resulting metabolic response varies greatly between individuals. Objective: We attempted to address the issue of individual differences in the response to weight cycling in male mice. Methods: We first exposed adult wild type mice to repeated cycles of high/low fat food. Next, using a lentiviral approach, we knocked-down or over-expressed miR-219 in the ventromedial hypothalamus (VMH) of an additional mouse cohort and performed a full metabolic assessment. Results: Exposure of wild type males to weight cycling resulted in the division of the cohort into subsets of resistant versus metabolic syndrome-prone (MS) animals, which differed in their metabolic profile and hypothalamic miR-219 levels. Lentiviral knock-down of miR-219 in the VMH led to exacerbation of metabolic syndrome. In contrast, over-expression of miR-219 resulted in moderation of the metabolic syndrome phenotype. Conclusions: Our results suggest a role for miR-219 in the mediation of the metabolic phenotype resulting from repeated weight cycling. (C) 2018 The Authors. Published by Elsevier GmbH.
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