期刊
STROKE AND VASCULAR NEUROLOGY
卷 3, 期 1, 页码 34-41出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/svn-2017-000123
关键词
stroke; infection; post-stroke immunosuppression
资金
- National Basic Research Program of China [2013CB966900]
- National Science Foundation of China [81230028, 81301044, 81471535]
- American Heart Association [16SDG27250236]
- National Institutes of Health [R01NS092713]
- National Multiple Sclerosis Society [RG-1507-05318]
Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients. Approaches for effective management of poststroke infection remain scarce, presenting an urgent need for preventive anti-infection strategies for patients who have suffered a stroke. Emerging evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections, suggesting that the modification of impaired immune defence could be beneficial. In this review, we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced immunosuppression. Further elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system.
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