期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
卷 6, 期 1, 页码 9-19出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jaip.2017.10.009
关键词
Indoor allergens; Environmental interventions; Asthma; Furry pet allergens; Mouse allergen; Cockroach allergen; Fungal allergens; Inner-city asthma; Childhood asthma
资金
- National Institutes of Health [K24 AI 114769, R01 ES 023447, R01 ES026170, U01 AI83238]
Over the last 2 to 3 decades, significant advances have been made in understanding the role that indoor allergen exposures play with regard to respiratory health. Multiple studies have confirmed that sensitization and exposure to indoor allergens can be a risk factor for asthma morbidity. Environmental interventions targeting key indoor allergens have been evaluated with the aims of examining their causal effects on asthma-related outcomes and identifying clinically efficacious interventions to incorporate into treatment recommendations. Historically, it appeared that the most successful intervention, as performed in the Inner-City Asthma Study, was individually tailored, targeting multiple allergens in a predominantly low-income, minority, and urban pediatric population. Recent studies suggest that single-allergen interventions may be efficacious when targeting the most clinically relevant allergen for a population. In this article, we review recent literature on home environmental interventions and their effects on specific indoor allergen levels and asthma-related outcomes. (C) 2017 American Academy of Allergy, Asthma & Immunology
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