期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 41, 期 11, 页码 1579-1585出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-010-1171-z
关键词
Allergy; Autism; Brain; Food intolerance; Inflammation; Mast cells
Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of allergic symptomatology, often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation.
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