期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00057
关键词
regulatory T cell; tTreg; iTreg; microRNA; graft-versus-host disease
类别
资金
- Children's Cancer Research Fund
- National Institutes of Health, National Heart, Lung and Blood Institute [R01 HL114512-01]
- National Cancer Institute [P01 CA142106, P01 CA047741, P01 CA065493]
- National Institutes of Health, National Institute of Allergy and Infectious Diseases [P01 AI056299, R01 AI11879, R37 AI344495]
- Leukemia & Lymphoma Society Translational Research grant [6458-15, 6462-15]
- Australian National Health and Medical Research Council (NHMRC) [APP1031728]
Regulatory T cells (Tregs) are key mediators of the immune system. MicroRNAs (miRNAs) are a family of similar to 22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNA regulates protein expression posttran-scriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout (KO) mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 KO mice.
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