期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00486
关键词
natural killer cells; CD161; pro-inflammatory cytokines; cytomegalovirus; human immunodeficiency virus; inflammatory bowel diseases
类别
资金
- Swiss National Science Foundation [33CS30_148522]
- SHCS research foundation
- Medical Research Council
- National Institute for Health Research (NIHR)
- Oxford Biomedical Research Centre (BRC)
- Nuffield Department of Clinical Medicine (Oxford)
- James Martin School for the 21st Century (Oxford)
- Wellcome Trust [WT091663MA]
- US National Institutes of Health [U19AI082630]
- MRC [MC_UU_12010/7, MC_UU_00008/7] Funding Source: UKRI
- Swiss National Science Foundation (SNF) [33CS30_148522] Funding Source: Swiss National Science Foundation (SNF)
CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells.
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