期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.01094
关键词
post-transcriptional RNA regulation; RNA binding proteins; immune cell development; immune cell homeostasis; immune cell activation; T-cell mediated immunity; humoral response
类别
资金
- ATIP-Avenir-Plan Cancer [C18003BS]
- Inserm-CNRS-University Paul Sabatier [U104318B]
- Biotechnology and Biological Sciences Research Council [BB/J004472/1, BB/J00152X/1]
- Wellcome Trust [200823/Z/16/Z]
- Bloodwise [14022]
- BBSRC [BB/J00152X/1] Funding Source: UKRI
Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient responses while preventing immunodeficiencies and autoimmunity. Post-transcriptional regulation of RNA editing, location, stability, and translation are the other key steps for final gene expression, and they are all controlled by RNA-binding proteins (RBPs). Nowadays we have a deep understanding of how transcription factors control the immune system but recent evidences suggest that post-transcriptional regulation by RBPs is equally important for both development and activation of immune responses. Here, we review current knowledge about how post-transcriptional control by RBPs shapes our immune system and discuss the perspective of RBPs being the key players of a hidden immune cell epitranscriptome.
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