期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.01119
关键词
CD4 T-cells; naive cells; Mycobacterium tuberculosis; tuberculosis; cytokines
类别
资金
- Ricerca Corrente of INMI
- Norwegian Agency for Development Cooperation (NORAD) through Tuberculosis Vaccine Initiative [1001143436007833]
- European Commission within the 7th Framework Programme, NEWTBVAC [HEALTH-F3-2009-241745]
- Horizon Programme TBVAC [643381]
- Horizon Programme EMI-TB [643558]
T-cell-mediated immune responses play a fundamental role in controlling Mycobacterium tuberculosis (M. tuberculosis) infection, and traditionally, this response is thought to be mediated by Th1-type CD4(+) T-cells secreting IFN-gamma. While studying the function and specificity of M. tuberculosis-reactive CD4(+ )T-cells in more detail at the single cell level; however, we found a human CD4(+ )T-cell population with a naive phenotype that interestingly was capable of producing multiple cytokines (T-CNP cells). CD4(+) T-CNP cells phenotyped as CD95(lo) CD28(int) CD49d(hi) CXCR3(hi )and showed a broad distribution of T cell receptor V beta segments. They rapidly secreted multiple cytokines in response to different M. tuberculosis antigens, their frequency was increased during active disease, but was comparable to latent tuberculosis infection in treated TB patients. These results identify a novel human CD4(+) T-cell subset involved in the human immune response to mycobacteria, which is present in active TB patients' blood. These results significantly expand our understanding of the immune response in infectious diseases.
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