期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00577
关键词
triggering receptor expressed on myeloid cells-1; streptococcal toxic-shock-like syndrome; Streptococcus suis; inflammation; cytokine storm
类别
资金
- National Key Research and Development Program of China [2017YFD0500204]
- National Natural Science Foundation of China [31272544]
- Natural Science Foundation of Hubei Province [2015CFA041, 2016CFA015]
- fundamental research funds for the central university [2662015PY221]
Streptococcus suis infections can cause septic shock, which is referred to as streptococcal toxic-shock-like syndrome (STSLS). The disease is characterized by a severe inflammatory response, multiple organ failure, and high mortality. However, no superantigen that is responsible for toxic shock syndrome was detected in S. suis, indicating that the mechanism underlying STSLS is different and remains to be elucidated. Triggering receptor expressed on myeloid cells-1 (TREM-1), belonging to the Ig superfamily, is an activating receptor expressed on myeloid cells, and has been recognized as a critical immunomodulator in several inflammatory diseases of both infectious and non-infectious etiologies. In this review, we discuss the current understanding of the immunoregulatory functions of TREM-1 on acute infectious diseases and then highlight the crucial roles of TREM-1 on the development of STSLS.
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