期刊
EMERGING INFECTIOUS DISEASES
卷 17, 期 12, 页码 2277-2286出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1712.110783
关键词
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资金
- National Institute of Health [RO1 AI 50529]
- Agence Nationale de Recherches stir le SIDA (ANRS) [12125/12182]
- Infectiopole Sud, France
Like most emerging infectious disease viruses, HIV is also of Zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of the Congo, we collected 330 samples derived from nonhuman primate bushmeat at 3 remote forest sites. SIV prevalences were estimated by using a novel high-throughput assay that included 34 HIV and SIV antigens in a single well. Overall, 19% of nonhuman primate bushmeat was infected with SIVs, and new SIV lineages were identified. Highest SIV prevalences were seen in red-tailed guenons (25%) and Tshuapa red colobus monkeys (24%), representing the most common hunted primate species, thus increasing the likelihood for cross-species transmission. Additional studies are needed to determine whether other SIVs crossed the species barrier. With the newly developed assay, large-scale screening against many antigens is now easier and faster.
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