期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.01462
关键词
interleukin-38; inflammation; signaling pathway; immune cell; autoimmunity
类别
资金
- National Natural Science Foundation of China [81701606]
- Sichuan Provincial Health and Family Planning Commission [16PJ284]
- Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic diseases [OIR17002A]
Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to several receptors, regulate the generation, function of inflammatory cytokines through the downstream signaling pathways. IL-38 is expressed in several tissues, such as placenta, heart, and brain. It is involved in a wide variety of diseases, including chronic inflammatory diseases. In this review, we discuss the expression and biological functions of IL-38, especially the role in rheumatic autoimmune diseases. Collection of the information may improve the understanding of IL-38, and may give potential for theoretical basis for clinical trials and drug development in the future.
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