期刊
CELLULAR & MOLECULAR BIOLOGY LETTERS
卷 16, 期 4, 页码 539-563出版社
VERSITA
DOI: 10.2478/s11658-011-0022-z
关键词
Protein disulfide isomerases; Calcitriol; STAT3; Cellular stress; Signal transduction; DNA repair
资金
- Enrico ed Enrica Sovena Foundation, Italy
The protein ERp57/GRP58 is a stress-responsive protein and a component of the protein disulfide isomerase family. Its functions in the endoplasmic reticulum are well known, concerning mainly the proper folding and quality control of glycoproteins, and participation in the assembly of the major histocompatibility complex class 1. However, ERp57 is present in many other subcellular locations, where it is involved in a variety of functions, primarily suggested by its participation in complexes with other proteins and even with DNA. While in some instances these roles need to be confirmed by further studies, a great number of observations support the participation of ERp57 in signal transduction from the cell surface, in regulatory processes taking place in the nucleus, and in multimeric protein complexes involved in DNA repair.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据