期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 6, 页码 3719-3724出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b08119
关键词
targeted gene delivery; core-shell; star polymer; ring opening polymerization; macrophage
资金
- National Natural Science Foundation of China [21474046]
- 1000 Young Talent Program
- Collaborative Innovation Center of Chemistry for Life Sciences
- Program for Changjiang Scholars and Innovative Research Team in University
In this report, two biodegradable star-shaped polyasparamide derivatives and four analogues modified with either mannose or folic acid moiety for preferential targeting of a difficult-to-transfect immune cell type, i.e., macrophage, have been synthesized. Each of the prepared star polymers complexes with plasmid DNA to form nanosized particles featuring a core shell-like morphology. Mannose or folate functionalized star polymers can greatly improve the transfection performance on a macrophage cell line RAW 264.7. As a result, a combination of targeting ligand modification and topological structures of gene carriers is a promising strategy for immune cells-based gene therapy.
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