期刊
ACS INFECTIOUS DISEASES
卷 4, 期 7, 页码 1041-1047出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.8b00112
关键词
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资金
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council
- Ontario Research Fund
- Canadian Glycomics Network
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen, designated by the World Health Organization as a critical priority for development of new therapeutics due to high levels of intrinsic and acquired antibiotic resistance. Other challenges include its versatility (it can persist in the environment and most strains are capable of causing disease in compromised hosts), robust efflux mechanisms that limit drug penetration, and the propensity to form antimicrobial-tolerant biofilms. Novel therapeutics in development to prevent or treat P. aeruginosa infections include vaccines, biologics such as antimicrobial peptides and therapeutic antibodies, virulence inhibitors, antimicrobials with novel targets, antibody-drug conjugates, resistance inhibitor-antibiotic or antibiotic-potentiator combinations, and bacteriophages or phage-derived lysins.
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