期刊
ACS INFECTIOUS DISEASES
卷 4, 期 5, 页码 673-685出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.7b00266
关键词
filovirus; Ebola virus; Marburg virus; countermeasure development; vaccine; therapeutic; animal models; rodent models; ferrets
资金
- Public Health Agency of Canada
- National Key Research and Development Program of China [2016YFE0205800]
- National Key Program for Infectious Disease of China [2016ZX10004222]
- Canadian Institutes of Health Research [IER-143487]
- Sanming Project of Medicine in Shenzhen [ZDSYS201504301534057]
- Shenzhen Science and Technology Research and Development Project [JCYJ20160427151920801]
- National Natural Science Foundation of China International Cooperation and Exchange Program [816110193]
The development of novel therapeutics and vaccines to treat or prevent disease caused by filoviruses, such as Ebola and Marburg viruses, depends on the availability of animal models that faithfully recapitulate clinical hallmarks of disease as it is observed in humans. In particular, small animal models (such as mice and guinea pigs) are historically and frequently used for the primary evaluation of antiviral countermeasures, prior to testing in nonhuman primates, which represent the gold-standard filovirus animal model. In the past several years, however, the filovirus field has witnessed the continued refinement of the mouse and guinea pig models of disease, as well as the introduction of the hamster and ferret models. We now have small animal models for most human-pathogenic filoviruses, many of which are susceptible to wild type virus and demonstrate key features of disease, including robust virus replication, coagulopathy, and immune system dysfunction. Although none of these small animal model systems perfectly recapitulates Ebola virus disease or Marburg virus disease on its own, collectively they offer a nearly complete set of tools in which to carry out the preclinical development of novel antiviral drugs.
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