期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 4, 期 3, 页码 1046-1054出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.8b00020
关键词
mesoporous silica; ZK60; degradation behavior; biocompatibility; microstructure
资金
- Natural Science Foundation of China [51575537, 81572577, 51705540]
- Hunan Provincial Natural Science Foundation of China [2016JJ1027]
- Project of Innovation-driven Plan of Central South University [2016CX023]
- Open-End Fund for the Valuable and Precision Instruments of Central South University
- State Key Laboratory of Solidification Processing at NWPU [SKLSP201605]
- Project of State Key Laboratory of High Performance Complex Manufacturing, Central South University
- National Postdoctoral Program for Innovative Talents [BX201700291]
- Project of Hunan Provincial Science and Technology Plan [2017RS3008]
- Fundamental Research Funds for the Central Universities of Central South University [2016zzts046]
Magnesium (Mg) alloys are potential bone implant materials because of their natural biodegradability, good biocompatibility and suitable mechanical properties. However, the too rapid degradation in physiological environment has delayed their introduction for orthopedic applications to date. To improve the degradation behavior, mesoporous silica (MS) was incorporated into ZK60 (Mg-6Zn-0.5Zr, wt %) via selective laser melting technology. Results showed that MS homogeneously incorporated in Mg matrix with good bonding interface. MS was chemical inert against Mg and shifted the corrosion potential positively, indicating an enhanced corrosion resistance. Moreover, MS promoted the deposition of apatite on surface and formed a compact protection layer, thus effectively preventing the further corrosion of Mg matrix. As a result, the degradation rate was reduced by 57%, with MS containing up to 8 wt %. In addition, ZK60/8MS composite exhibited improved biocompatibility. It was suggested the ZK60/8MS composite with improved degradation behavior and good biocompatibility was a potential candidate biomaterial for the bone implants.
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