期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 4, 期 3, 页码 872-883出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00818
关键词
self-healing hydrogel; double cross-linked network; acid resistant; Diels-Alder click chemistry; imine bond
资金
- NSFC [21371042, 21271056, 21571044]
- Thirteen Five National Key Research and Development Projects [2016YFC0500307-07]
- Heilongjiang Province major research projects [GA13B202]
- NSF of Heilongjiang Province [B2015003, ZD2015001, JJ2016JQ0037, H2015065]
A novel biocompatible polysaccharide-based hydrogel with double cross-linked network (DN) was designed and developed by combining dynamic imine bond and Diels-Alder (DA) click reaction. Our results showed that the dynamic covalent imine bond led to the hydrogel's self-healing property, while the DA reaction gave the superior thermodynamic property and acid resistance to the hydrogel. At the same time, the double cross-linked structure improved the mechanical properties of hydrogels. Moreover, the DN hydrogel had good biocompatibility, as confirmed by three-dimensional cell encapsulation. On the basis of these excellent properties, the present prepared hydrogel holds great potential in the field of biomaterials.
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