期刊
PEERJ
卷 6, 期 -, 页码 -出版社
PEERJ INC
DOI: 10.7717/peerj.4303
关键词
Microbiome; Gut; Human; Population; Networks; Co-occurrence; Communities
资金
- National Institutes of Health (NIH) [RO1 DK093595, DP2 OD007444]
- Wellcome Trust
- European Community's Seventh Framework Programme (FP7)
- National Institute for Health Research (NIHR) - BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust
- King's College London
- Chronic Disease Research Foundation (CDRF)
- Engineering and Physical Sciences Research Council (EPSRC)
- Bulgarian NSF [I 02/19]
- Top Institute Food and Nutrition, Wageningen, the Netherlands [TiFN GH001]
- Netherlands Organization for Scientific Research (NWO) [NWO-VIDI 864.13.013]
- CardioVa sculair Onderzoek Nederland [CVON 2012-03]
- ERC-START grant [ERC-715772]
- University of Groningen
- MRC [MR/N01183X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [1231308] Funding Source: researchfish
- Medical Research Council [MR/N01183X/1] Funding Source: researchfish
Microbes in the gut microbiome form sub-communities based on shared niche specialisations and specific interactions between individual taxa. The inter-microbial relationships that define these communities can be inferred from the co-occurrence of taxa across multiple samples. Here, we present an approach to identify comparable communities within different gut microbiota co-occurrence networks, and demonstrate its use by comparing the gut microbiota community structures of three geographically diverse populations. We combine gut microbiota profiles from 2,764 British, 1,023 Dutch, and 639 Israeli individuals, derive co-occurrence networks between their operational taxonomic units, and detect comparable communities within them. Comparing populations we find that community structure is significantly more similar between datasets than expected by chance. Mapping communities across the datasets, we also show that communities can have similar associations to host phenotypes in different populations. This study shows that the community structure within the gut microbiota is stable across populations, and describes a novel approach that facilitates comparative community-centric microbiome analyses.
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