期刊
NEUROIMAGE-CLINICAL
卷 19, 期 -, 页码 507-515出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2018.05.015
关键词
Dynamic functional connectivity; Functional connectivity; Information processing speed; Default mode network; Cognition; Multiple sclerosis
类别
资金
- Novartis
- Branco Weiss Fellowship from Society in Science
- Dutch MS Research Foundation
- Merck Serono
- Biogen
- TEVA
- Genzyme
- Roche
- Dutch MS Research Foundation [08-648]
Objective: To explore the added value of dynamic functional connectivity (dFC) of the default mode network (DMN) during resting-state (RS), during an information processing speed (IPS) task, and the within-subject difference between these conditions, on top of conventional brain measures in explaining IPS in people with multiple sclerosis (pwMS). Methods: In 29 pwMS and 18 healthy controls, IPS was assessed with the Letter Digit Substitution Test and Stroop Card I and combined into an IPS-composite score. White matter (WM), grey matter (GM) and lesion volume were measured using 3 T MRI. WM integrity was assessed with diffusion tensor imaging. During RS and task-state fMRI (i.e. symbol digit modalities task, IPS), stationary functional connectivity (sFC; average connectivity over the entire time series) and dFC (variation in connectivity using a sliding window approach) of the DMN was calculated, as well as the difference between both conditions (i.e. task-state minus RS; Delta sFC-DMN and Delta dFC-DMN). Regression analysis was performed to determine the most important predictors for IPS. Results: Compared to controls, pwMS performed worse on IPS-composite (p=0.022), had lower GM volume (p < 0.05) and WM integrity (p < 0.001), but no alterations in sFC and dFC at the group level. In pwMS, 52% of variance in IPS-composite could be predicted by cortical volume (beta=0.49, p=0.01) and Delta dFC-DMN (beta=0.52, p < 0.01). After adding dFC of the DMN to the model, the explained variance in IPS increased with 26% (p < 0.01). Conclusion: On top of conventional brain measures, dFC from RS to task-state explains additional variance in IPS. This highlights the potential importance of the DMN to adapt upon cognitive demands to maintain intact IPS in pwMS.
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