期刊
NEUROIMAGE-CLINICAL
卷 17, 期 -, 页码 452-464出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2017.09.016
关键词
Amyloid imaging; Tau imaging; Brain atrophy; Alzheimer's Disease; Dementia
类别
资金
- Italian Ministry of Education, University and Research (MIUR) (Ministerial Fellowship
- National Institute of Neurological Disorders and Stroke [R01-NS050915]
- National Institute on Deafness and Other Communication Disorders [K24 - DC015544]
- National Institutes of Health [K23-AG048291, U54-NS092089, R01-AG038791, U01-AG045390]
- National Institute on Aging [R01-AG045611, R01-AG034570, P50-AG023501, F32-AG050389]
- Tau Consortium
- State of California Department of Health Services Alzheimer's Disease Research Centre of California grant [04-33516]
- John Douglas French Alzheimer's Foundation
- Marie Curie FP7 International Outgoing Fellowship [628812]
- University of California
- CBD Solutions
- Bluefield Project to Cure FTD
- Alzheimer's Association
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U54NS092089, R01NS050915] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K23AG048291, R01AG045611, P50AG023501, R01AG038791, R01AG034570, F32AG050389] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [K24DC015544] Funding Source: NIH RePORTER
The relationships between beta-amyloid (A beta), tau and neurodegeneration within Alzheimer's Disease pathogenesis are not fully understood. To explore these associations in vivo, we evaluated 30 A beta PET-positive patients (mean +/- sd age 62.4 +/- 8.3) with mild probable AD and 12 A beta PET-negative healthy controls (HC) (mean +/- sd age 77.3 +/- 6.9) as comparison. All participants underwent 3 T MRI, C-11-PiB (A beta) PET and (18)FA-V1451 (tau) PET. Multimodal correlation analyses were run at both voxel-and region-of-interest levels. C-11-PiB retention in AD showed the most diffuse uptake pattern throughout association neocortex, whereas F-18-AV1451 and gray matter volume reduction (GMR) showed a progressive predilection for posterior cortices (p<0.05 Family-Wise Error-[FWE]-corrected). Voxel-level analysis identified negative correlations between F-18-AV1451 and gray matter peaking in medial and infero-occipital regions (p<0.01 False Discovery Rate-[FDR]-corrected). F-18-AV1451 and C-11-PiB were positively correlated in right parietal and medial/inferior occipital regions (p<0.001 uncorrected). C-11-PiB did not correlate with GMR at the voxel-level. Regionally, F-18-AV1451 was largely associated with local/adjacent GMR whereas frontal C-11-PiB correlated with GMR in posterior regions. These findings suggest that, in mild AD, tau aggregation drives local neurodegeneration, whereas the relationships between A beta and neurodegeneration are not region specific and may be mediated by the interaction between A beta and tau.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据