期刊
NEUROIMAGE-CLINICAL
卷 17, 期 -, 页码 1-9出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2017.09.017
关键词
Disorders of consciousness; Spinal cord stimulation; Functional near-infrared spectroscopy; Inter-stimulus interval; Prefrontal cortex
类别
资金
- National Key Research and Development Program of China [2017YFB1002502]
- National Natural Science Foundation of China [31571003, 81501550, 81600919]
- National Natural Science Foundation of Beijing [7164302]
Spinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize the protocol, previous studies evaluated the frequency-specific effects of SCS on neurophysiological activities. However, whether and how the inter-stimulus interval (ISI) parameter affects the SCS neuromodulation in DOC remains unknown. We enrolled nine DOC patients who had implanted SCS devices and conducted three different durations of ISIs. Using functional near-infrared spectroscopy (fNIRS), we monitored the blood volume fluctuations in the prefrontal and occipital cortices during the SCS. The results showed that short stimuli (30 s) induced significant cerebral blood volume changes, especially in the prefrontal cortex, an important area in the consciousness system. By comparing the mean value of the responses from the first and the last block in each session, a shorter ISI was found to improve the blood volume in the prefrontal cortex. This phenomenon was more significant for the subgroup of patients with a favorable prognosis. These preliminary results imply that the ISI may be an important factor for SCS. The research paradigm proposed here also provides insights for further quantitative evaluations of the therapeutic effects of neuromodulation.
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