期刊
NEUROIMAGE-CLINICAL
卷 17, 期 -, 页码 786-793出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2017.12.011
关键词
Affective disorders; Structural MRI; Anterior cingulate cortex; VBM
类别
资金
- Mental Health Services, Capital Region of Denmark
- Lundbeck Foundation [R59-A5399]
- Novo Nordisk Foundation Interdisciplinary Synergy Program [NNF14OC0011413]
Background: Major depression and bipolar disorders aggregates in families and are linked with a wide range of neurobiological abnormalities including cortical gray matter (GM) alterations. Prospective studies of individuals at familial risk may expose the neural mechanisms underlying risk transmission. Methods: We used voxel based morphometry to investigate changes in regional GM brain volume, over a seven-year period, in 37 initially healthy individuals having a mono-or di-zygotic twin diagnosed with major depression or bipolar disorder (high-risk group; mean age 41.6 yrs.) as compared to 36 individuals with no history of affective disorders in the index twin and first-degree relatives (low-risk group; mean age 38.5 yrs.). Results: Groups did not differ in regional GM volume changes over time. However, independent of time, high-risk twins had significantly greater GM volumes in bilateral dorsal anterior cingulate, inferior frontal gyrus and temporoparietal regions as compared to low-risk twins. Further, individuals who developed an affective disorder at follow-up (n = 12), had relatively the largest GM volumes, both at baseline and follow-up, in the right dorsal anterior cingulate cortex and right inferior frontal cortex compared to high-and low-risk twins who remained well at follow-up. Conclusion: This pattern of apparently stable grater regional GM volume may constitute a neural marker of an increased risk for developing an affective disorder in individuals at familial risk.
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